Posted in | Optics and Photonics

Movement of M1 Molecules in Living CHO Cells

This video shows the movement of M1 muscarinic acetylcholine receptor molecules labelled with florescent ligand Cy3B--telenzepine in living CHO cells using TIRFM (total internal reflection fluorescence microscopy) and Andor iXon EMCCD camera.

The M1 molecules undergo unrestricted pseudo 1-D diffusion on filopodia membrane and 2-D diffusion on plasma membrane. Muscarinic acetylcholine receptors are the members of the superfamily of GPCR.

Run Time – 0:06sec

Single molecules of M1 receptior on plasma mebrane of CHO cell

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