Best of two worlds: combining optical tweezers with time-resolved confocal microscopy

As a joint development, PicoQuant and Ionovation combined time-resolved microscopy and optical tweezers in a single system. Both instruments retain their individual functionalities but can also be used together, thus enabling customers to carry out time-resolved fluorescence microscopy (e.g. fluorescence lifetime imaging) on trapped objects such as cells.

Time-resolved microscopy and optical tweezers combined in a single system.

PicoQuant and Ionovation will showcase the features of this combined system at the 62nd Biophysical Society Meeting in San Francisco (February 17- 21, 2018).

PicoQuant‘s MicroTime 200 platform is the most flexible and extensible high-end research tool for time-resolved fluorescence microscopy requiring single molecule sensitivity. The system is an excellent choice for many methods, including Pulsed Interleaved Excitation (PIE), Förster Resonance Transfer (FRET), Stimulated Emission Depletion (STED) super-resolution microscopy, Fluorescence (Lifetime) Correlation Spectroscopy (F(L)CS), and anisotropy measurements.

Ionovation’s PicoTweezers system is a compact, robust trapping and force measurement device based on the  “optical tweezers” concept which is equipped with real-time video detection. In contrast to common optical tweezers systems, PicoTweezers has no spatial restrictions and is compatible to all sample carriers. The system is well suited for molecular interaction studies, force spectroscopy, cell trapping, rheology and many other applications.

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