Laser Microdissection for Life Science Applications with the Carl Zeiss PALM Microbeam IV

Carl Zeiss MicroImaging GmbH, a leading provider of microscopy solutions for a variety of research, clinical and industrial applications, introduces the PALM MicroBeam IV, a system designed to cleanly extract even the smallest biomaterials from heterogeneous tissue and cell colonies. The patented Laser Microdissection and Pressure Catapulting (LMPC) process at the core of the PALM MicroBeam provides a pure and contact-free optical technique that is gentle enough to facilitate microdissection and manipulation of even living cells in culture.

The PALM MicroBeam enables users to harvest ultra-pure biomolecules for downstream research. Researchers can refine raw materials right on the microscope slide or inside the culture dish by visual and automatic identification, outlining the relevant area for non-contact extraction via fully-automated laser ablation. After a clear separation between the wanted and unwanted material is established, a laser pulse delivers mechanical force to the sample, catapulting the specimen toward the receptacle for further viewing.

The PALM MicroBeam boasts an ergonomic, intuitive design, affording users rapid, unimpeded experimentation in a variety of conditions. The system adjusts easily to a variety of source material, and the inverted configuration optimizes work with both membrane-coated slides, and glass slides with archived specimen.

With the high-performance optics of the Axio Observer inverted research microscope and the AxioVision software for automatic object recognition, the PALM MicroBeam is at the forefront of life science research. Multichannel fluorescence and automated image analysis ensure that even the weakest fluorescence signals can be visualized brilliantly. Available in several configurations ranging from single experiment systems to high content, integrated imaging workstations, the PALM MicroBeam achieves optimal workflow for routine and challenging microdissection applications.

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