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Nanoscopic Imaging of Neuroendocrine Regulatory Processes with Super-Resolution Techniques

Guest speaker Dr. Thomas Stroh, Assistant Professor at Montreal Neurological Institute, McGill University, Canada, is presenting a webinar on Nanoscopic Imaging of Neuroendocrine Regulatory Processes Using Super-Resolution Microscopy.

Dr. Stroh is a leading researcher in the field of G protein-coupled receptors. His work focuses on studying the mechanisms governing the availability of receptors at the cell surface of neurons and neuroendocrine cells, factors that can ultimately determine their sensitivity to transmitters, neuropeptides, and active agents.

Key topics include:

  • Exploring advanced super-resolution microscopy techniques, such as dSTORM (direct Stochastic Optical Reconstruction Microscopy) and biplane SMLM (single-molecule localization microscopy), to visualize neuroendocrine regulatory processes in the brain at near-molecular resolution.
  • Integrating super-resolution imaging with plasma hormone level testing to investigate how receptors are trafficked and how synaptic remodeling occurs in neuroendocrine circuits within pituitary cells and brain tissue.
  • Measuring synaptic remodeling influenced by hormonal cycles, based on groundbreaking studies in mouse brain models.

About the Speaker

Associate Professor Thomas Stroh brings over 20 years of expertise in microscopy and neurobiology. In 2005, he founded the Neuro Microscopy Core Facility at the Montreal Neurological Institute (The Neuro) of McGill University. This state-of-the-art facility has grown into a cutting-edge microscopy hub, offering technologies ranging from live-cell imaging to fluorescence super-resolution microscopy. Today, it supports more than 50 laboratories, including those at The Neuro, various McGill departments, other Montreal universities, and industry partners.

Dr. Stroh has shared his knowledge widely, teaching at workshops and microscopy summer schools such as the Montreal Light Microscopy Course and the Canadian Light Microscopy Course at the University of Calgary. In collaboration with Dr. Claire Brown from McGill’s Advanced BioImaging Facility (ABIF), he co-organized the first Canadian Quantitative Super-Resolution Microscopy Course at The Neuro in 2019. Dr. Stroh also serves on the Executive Board of the Canada BioImaging Network.

His research primarily focuses on the regulation and trafficking of G Protein-Coupled Receptors. More recently, his lab has been pioneering approaches that combine super-resolution microscopy with highly sensitive plasma hormone level testing to explore how natural rhythms influence synaptic connectivity and plasticity in the hypothalamus.

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